The most common primary topics of investigation were energy-related flow parameters, flow components and vortex analysis which demonstrated potentials for quantifying early diastolic dysfunc-tion, whilst other parameters including haemodynamic forces, residence time distribution and turbulent kinetic energy remain in need of further evaluation. All the studies were small-scale feasibility or pilot studies investigating a diverse range of flow parameters. There was considerable variability in the reporting of methodologies and analyses. All the included studies were ranked as "highly clinically appli-cable". A total of 1186 articles were identified, and 30 articles were included in the final analysis. A comprehensive literature search was performed in March 2022 on available databases. We performed a systematic review of current literature on the role of 4D-flow MRI-derived flow parameters in quantification of LV function with a focus on potential clinical applicability. There is increasing recognition of the value of four-dimensional flow cardiovascular magnetic resonance (4D-flow MRI) as a potential means to detect and measure abnormal flow behaviour that occurs during early left ventricular (LV) dysfunction. To avoid cluttered view, only large scale vortex cores of 1 cm3 or larger are visualized. Lambda2 isovalue threshold T λ 2 = 3 μ was used to define the isosurfaces of vortex ring cores (with μ as the λ2 average of voxels with λ2 < 0). With the start of diastolic phase (f1),the start of the presence of a compact ring-like shaped vortex ring during early- (f3) and late (f7) diastolic filling, the most developed vortex ring formed during early-(f5) and A-filling (f18), the start of vortex stretching or elongation in direction parallel to the LV long-axis (f10) and end of late filling while compact vortex ring is still identifiable (f19). Every dot in the cardiac curve corresponds to a time point of the cardiac cycle in which a 4D Flow volume was acquired. Diastasis is the duration between z and u. Time-sequence of the Lambda2-detected 3D LV vortex structures (visualized as isosurfaces in red color) over all acquired diastolic phases of a sample normal subject, with E-filling onset (x), peak (y) and end (z), and A-filling onset (u), peak (v) and end (w).